Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens.

Bibliographic Details
Main Authors: Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson, Jiang Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12040

Internet

https://doi.org/10.1038/ncomms12040

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