Assessing cell-specific effects of genetic variations using tRNA microarrays

Assessing cell-specific effects of genetic variations using tRNA microarrays

Abstract Background By definition, effect of synonymous single-nucleotide variants (SNVs) on protein folding and function are neutral, as they alter the codon and not the encoded amino acid. Recent examples indicate tissue-specific and transfer RNA (tRNA)-dependent effects of some genetic variations...

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Bibliographic Details
Main Authors: Christine Polte, Daniel Wedemeyer, Kathryn E. Oliver, Johannes Wagner, Marcel J. C. Bijvelds, John Mahoney, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Genomics
Subjects:
Nucleotide variants
Synonymous single nucleotide polymorphisms
tRNA
Protein translation
Cystic fibrosis
Online Access:http://link.springer.com/article/10.1186/s12864-019-5864-1

Internet

http://link.springer.com/article/10.1186/s12864-019-5864-1

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