Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1

Tumor suppressor SMAR1 regulates PKM alternative splicing by HDAC6-mediated deacetylation of PTBP1

Abstract Background Highly proliferating cancer cells exhibit the Warburg effect by regulation of PKM alternative splicing and promoting the expression of PKM2. Majority of the alternative splicing events are known to occur in the nuclear matrix where various MARBPs actively participate in the alter...

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Bibliographic Details
Main Authors: Arpankumar Choksi, Apoorva Parulekar, Richa Pant, Vibhuti Kumar Shah, Ramakrishna Nimma, Priyanka Firmal, Smriti Singh, Gopal C. Kundu, Sanjeev Shukla, Samit Chattopadhyay
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Cancer & Metabolism
Subjects:
SMAR1
PKM1
PKM2
HDAC6
PTBP1
Alternative splicing
Online Access:https://doi.org/10.1186/s40170-021-00252-x

Internet

https://doi.org/10.1186/s40170-021-00252-x

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