Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19

Clinical evidence of an interferon–glucocorticoid therapeutic synergy in COVID-19

Abstract Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity and can be directly suppressed by glucocorticoids. To investigate whether therapeut...

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Bibliographic Details
Main Authors: Yingying Lu, Feng Liu, Gangling Tong, Feng Qiu, Pinhong Song, Xiaolin Wang, Xiafei Zou, Deyun Wan, Miao Cui, Yunsheng Xu, Zhihua Zheng, Peng Hong
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00496-5

Internet

https://doi.org/10.1038/s41392-021-00496-5

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