TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

TGF-β1 Negatively Regulates the Number and Function of Hematopoietic Stem Cells

Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity. To examine the effect of TGF-β1 on the HSC function, w...

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Bibliographic Details
Main Authors: Xiaofang Wang, Fang Dong, Sen Zhang, Wanzhu Yang, Wenying Yu, Zhao Wang, Shanshan Zhang, Jinhong Wang, Shihui Ma, Peng Wu, Yun Gao, Ji Dong, Fuchou Tang, Tao Cheng, Hideo Ema
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671118302352

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http://www.sciencedirect.com/science/article/pii/S2213671118302352

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