Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

Abstract Background The term systemic juvenile idiopathic arthritis (sJIA) describes an autoinflammatory condition characterized by arthritis and severe systemic inflammation, which in later stages can transform into interleukin (IL)-17-driven autoimmune arthritis. IL-1 antagonists have been used wi...

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Bibliographic Details
Main Authors: Boris Hügle, Anastasia Schippers, Nadine Fischer, Kim Ohl, Bernd Denecke, Fabio Ticconi, Bas Vastert, Ivan G. Costa, Johannes-Peter Haas, Klaus Tenbrock
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Arthritis Research & Therapy
Subjects:
Juvenile systemic arthritis
Juvenile idiopathic arthritis
RNA expression
HLA-DRB1
CD74
CD177
Online Access:http://link.springer.com/article/10.1186/s13075-018-1603-2

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http://link.springer.com/article/10.1186/s13075-018-1603-2

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