Preserved Cerebral Oxygen Metabolism in Astrocytic Dysfunction: A Combination Study of <sup>15</sup>O-Gas PET with <sup>14</sup>C-Acetate Autoradiography

Preserved Cerebral Oxygen Metabolism in Astrocytic Dysfunction: A Combination Study of <sup>15</sup>O-Gas PET with <sup>14</sup>C-Acetate Autoradiography

Fluorocitrate (FC) is a specific metabolic inhibitor of the tricarboxylic acid (TCA) cycle in astrocytes. The purpose of this study was to evaluate whether inhibition of the astrocyte TCA cycle by FC would affect the oxygen metabolism in the rat brain. At 4 h after the intracranial FC injection, the...

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Bibliographic Details
Main Authors: Carla Mari Macaisa, Tadashi Watabe, Yuwei Liu, Victor Romanov, Yasukazu Kanai, Genki Horitsugi, Hiroki Kato, Eku Shimosegawa, Jun Hatazawa
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Brain Sciences
Subjects:
fluorocitrate
astrocyte
oxygen consumption
TCA cycle
<sup>15</sup>O-gas PET
cerebral blood flow
cerebral metabolic rate of oxygen
<sup>14</sup>C-acetate
Online Access:https://www.mdpi.com/2076-3425/9/5/101

Internet

https://www.mdpi.com/2076-3425/9/5/101

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