Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway

Abstract Background Signaling pathways critical for embryonic development re-emerge in adult pancreas during tumorigenesis. Aspartate β-hydroxylase (ASPH) drives embryonic cell motility/invasion in pancreatic development/differentiation. We explored if dysregulated ASPH is critically involved in pan...

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Bibliographic Details
Main Authors: Kosuke Ogawa, Qiushi Lin, Le Li, Xuewei Bai, Xuesong Chen, Hua Chen, Rui Kong, Yongwei Wang, Hong Zhu, Fuliang He, Qinggang Xu, Lianxin Liu, Min Li, Songhua Zhang, Katsuya Nagaoka, Rolf Carlson, Howard Safran, Kevin Charpentier, Bei Sun, Jack Wands, Xiaoqun Dong
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Hematology & Oncology
Subjects:
Aspartate β-hydroxylase
Invadopodium
Pancreatic ductal adenocarcinoma
Patient-derived xenograft
Metastasis
SRC
Online Access:https://doi.org/10.1186/s13045-019-0837-z

Internet

https://doi.org/10.1186/s13045-019-0837-z

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