Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

Like normal stem cells, tumor-initiating cells (T-ICs) are regulated extrinsically within the tumor microenvironment. Because HCC develops primarily in the context of cirrhosis, in which there is an enrichment of activated fibroblasts, we hypothesized that cancer-associated fibroblasts (CAFs) would...

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Bibliographic Details
Main Authors: Eunice Yuen Ting Lau, Jessica Lo, Bowie Yik Ling Cheng, Mark Kin Fai Ma, Joyce Man Fong Lee, Johnson Kai Yu Ng, Stella Chai, Chi Ho Lin, Suk Ying Tsang, Stephanie Ma, Irene Oi Lin Ng, Terence Kin Wah Lee
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cell Reports
Subjects:
cancer-associated fibroblasts (CAFs)
FRA1
HEY1
hepatocyte growth factor (HGF)
tumor-initiating cells (T-ICs)
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716304326

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http://www.sciencedirect.com/science/article/pii/S2211124716304326

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