Etanercept Inhibits B Cell Differentiation by Regulating TNFRII/TRAF2/NF-κB Signaling Pathway in Rheumatoid Arthritis

Etanercept Inhibits B Cell Differentiation by Regulating TNFRII/TRAF2/NF-κB Signaling Pathway in Rheumatoid Arthritis

ObjectiveTo explore the role of B cells in rheumatoid arthritis (RA) and the potential effects and mechanisms of etanercept on B cells.MethodsIn RA patients, the levels of tumor necrosis factor-α (TNF-α) and B cell activating factor (BAFF) were detected by ELISA. The percentage of B cell subsets was...

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Bibliographic Details
Main Authors: Xiao-Yu Cai, Yue Zhu, Chen Wang, Xiao-Yu Tang, Le Han, Jin-Ling Shu, Xian-Zheng Zhang, Fa-Qin Liang, Jing-Ru Ge, Li Xu, Dan Mei, Ling-Ling Zhang, Wei Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
rheumatoid arthritis
etanercept
TNF-α
B cell differentiation
NF-κB pathway
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00676/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00676/full

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