Active-site solvent replenishment observed during human carbonic anhydrase II catalysis

Active-site solvent replenishment observed during human carbonic anhydrase II catalysis

Human carbonic anhydrase II (hCA II) is a zinc metalloenzyme that catalyzes the reversible hydration/dehydration of CO2/HCO3−. Although hCA II has been extensively studied to investigate the proton-transfer process that occurs in the active site, its underlying mechanism is still not fully understoo...

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Bibliographic Details
Main Authors: Jin Kyun Kim, Carrie L. Lomelino, Balendu Sankara Avvaru, Brian P. Mahon, Robert McKenna, SangYoun Park, Chae Un Kim
Format: Article
Language:English
Published: International Union of Crystallography 2018-01-01
Series:IUCrJ
Subjects:
carbonic anhydrase II
proton transfer
water dynamics
high-pressure cryocooling
active-site solvent replenishment
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2052252517017626

Internet

http://scripts.iucr.org/cgi-bin/paper?S2052252517017626

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