Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6

Long non-coding RNA RP11-468E2.5 curtails colorectal cancer cell proliferation and stimulates apoptosis via the JAK/STAT signaling pathway by targeting STAT5 and STAT6

Abstract Background Long non-coding RNAs (lncRNAs) are tumor-associated biological molecules and have been found to be implicated in the progression of colorectal cancer (CRC). This study aims to examine the effects of lncRNA RP11-468E2.5 and its target genes (STAT5 and STAT6) on the biological acti...

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Bibliographic Details
Main Authors: Li Jiang, Xu-Hai Zhao, Yin-Ling Mao, Jun-Feng Wang, Hui-Jun Zheng, Qing-Shan You
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Long non-coding RNA RP11-468E2.5
Colorectal cancer
STAT5 gene
STAT6 gene
Janus kinase-signal transducer and activator of transcription signaling pathway
Proliferation
Online Access:http://link.springer.com/article/10.1186/s13046-019-1428-0

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http://link.springer.com/article/10.1186/s13046-019-1428-0

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