<span style="font-variant: small-caps">d</span>-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

<span style="font-variant: small-caps">d</span>-Amino Acid Substitution of α-Conotoxin RgIA Identifies its Critical Residues and Improves the Enzymatic Stability

&#945;-Conotoxin RgIA is a selective and potent competitive antagonist of rat &#945;9&#945;10 nicotinic acetylcholine receptors (nAChR), but it is much less potent towards human &#945;9&#945;10 nAChR. Furthermore, RgIA is susceptible to proteolytic degradation due to containing f...

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Bibliographic Details
Main Authors: Jie Ren, Xiaopeng Zhu, Pan Xu, Rui Li, Ying Fu, Shuai Dong, Dongting Zhangsun, Yong Wu, Sulan Luo
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Marine Drugs
Subjects:
<span style="font-variant: small-caps">d</span>-amino acid scan
α-conotoxin RgIA
α9α10 nAChR
activity
stability
Online Access:https://www.mdpi.com/1660-3397/17/3/142

Internet

https://www.mdpi.com/1660-3397/17/3/142

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