DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

DNA methylation in AgRP neurons regulates voluntary exercise behavior in mice

AgRP neurons in the hypothalamic arcuate nucleus (ARH) are involved in regulating hunger and energy balance. Here the authors show that knockout of the DNA methyltransferase Dnmt3a in AgRP neurons of the ARH leads to a reduction in voluntary exercise along with numerous epigenetic and gene expressio...

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Bibliographic Details
Main Authors: Harry MacKay, C. Anthony Scott, Jack D. Duryea, Maria S. Baker, Eleonora Laritsky, Amanda E. Elson, Theodore Garland Jr., Marta L. Fiorotto, Rui Chen, Yumei Li, Cristian Coarfa, Richard B. Simerly, Robert A. Waterland
Format: Article
Language:English
Published: Nature Publishing Group 2019-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13339-3

Internet

https://doi.org/10.1038/s41467-019-13339-3

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