Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Pharmacogenetics of glucocorticoid replacement could optimize the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

INTRODUCTION: 21-hydroxylase deficiency is an autosomal recessive disorder that causes glucocorticoid deficiency and increased androgen production. Treatment is based on glucocorticoid replacement; however, interindividual variability in the glucocorticoid dose required to achieve adequate hormonal...

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Bibliographic Details
Main Authors: Ricardo P. P. Moreira, Alexander A. L. Jorge, Larissa G. Gomes, Laura C. Kaupert, João Massud Filho, Berenice B. Mendonca, Tânia A. S. S. Bachega
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2011-01-01
Series:Clinics
Subjects:
21-hydroxylase deficiency
Glucocorticoid replacement therapy
Pharmacogenetics
Polymorphism
CYP3A7*1C allele
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322011000800009

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