The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

The Duffy binding protein as a key target for a Plasmodium vivax vaccine: lessons from the Brazilian Amazon

Plasmodium vivax infects human erythrocytes through a major pathway that requires interaction between an apical parasite protein, the Duffy binding protein (PvDBP) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC). The importance of the interaction between PvDBP (re...

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Bibliographic Details
Main Authors: Taís Nóbrega de Sousa, Flora Satiko Kano, Cristiana Ferreira Alves de Brito, Luzia Helena Carvalho
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2014-08-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
malaria
Plasmodium vivax
Duffy binding protein
naturally acquired antibodies
genetic variability
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762014000500608&lng=en&tlng=en

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