Compound 18 Improves Glucose Tolerance in a Hepatocyte TGR5-dependent Manner in Mice

The bile acid receptor, TGR5, is a key regulator of glucose homeostasis, but the mechanisms by which TGR5 signaling improves glucose regulation are incompletely defined. In particular, TGR5 has an increasingly appreciated role in liver physiology and pathobiology; however, whether TGR5 signaling wit...

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Bibliographic Details
Main Authors: Marlena M. Holter, Margot K. Chirikjian, Adriano Maida, Daniel A. Briere, Kyle W. Sloop, Kristina Schoonjans, Bethany P. Cummings
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Nutrients
Subjects:
Online Access:https://www.mdpi.com/2072-6643/12/7/2124