D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs

D701N mutation in the PB2 protein contributes to the pathogenicity of H5N1 avian influenza viruses but not transmissibility in guinea pigs

H5N1 highly pathogenic avian influenza virus (HPAIV) of clade 2.3.2 has been circulating in waterfowl in Southern China since 2003. Our previous studies showed that certain H5N1 HPAIV isolates within clade 2.3.2 from Southern China had high pathogenicity in different birds. Guinea pigs have been suc...

Full description

Bibliographic Details
Main Authors: Peirong eJiao, Liangmeng eWei, Yafen eSong, Jin eCui, Hui eSong, Lan eCao, Runyu eYuan, Kaijian eLuo, Ming eLiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Microbiology
Subjects:
Guinea Pigs
Mice
pathogenicity
transmissibility
H5N1 HPAIVs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00642/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00642/full

Similar Items