Rare Variants in Neurodegeneration Associated Genes Revealed by Targeted Panel Sequencing in a German ALS Cohort

Rare Variants in Neurodegeneration Associated Genes Revealed by Targeted Panel Sequencing in a German ALS Cohort

Amyotrophic lateral sclerosis (ALS) is a progressive fatal multisystemic neurodegenerative disorder caused by preferential degeneration of upper and lower motor neurons. To further delineate the genetic architecture of the disease, we used comprehensive panel sequencing in a cohort of 80 German ALS...

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Bibliographic Details
Main Authors: Stefanie Krüger, Florian Battke, Andrea Sprecher, Marita Munz, Matthis Synofzik, Ludger Schöls, Thomas Gasser, Torsten Grehl, Johannes Prudlo, Saskia Biskup
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Amyotrophic Lateral Sclerosis
Genetic Heterogeneity
neurodegeneration
next generation sequencing
polygenic inheritance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00092/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00092/full

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