Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis

Arcyriaflavin a, a cyclin D1–cyclin-dependent kinase4 inhibitor, induces apoptosis and inhibits proliferation of human endometriotic stromal cells: a potential therapeutic agent in endometriosis

Abstract Background We previously showed that microRNA-503 (miR-503) transfection into endometriotic cyst stromal cells (ECSCs) induced cell cycle arrest at the G0/G1 phase by suppressing cyclin D1. This finding prompted us to evaluate the potential therapeutic effects of cyclin D1 inhibitors in end...

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Bibliographic Details
Main Authors: Tomoko Hirakawa, Kaei Nasu, Yoko Aoyagi, Kanetoshi Takebayashi, Hisashi Narahara
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Endometriosis
Cyclin D1 inhibitor
Cell cycle
Apoptosis
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s12958-017-0272-3

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http://link.springer.com/article/10.1186/s12958-017-0272-3

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