Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision

Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision

Abstract Decreased sequencing costs have led to an explosion of genetic and genomic data. These data have revealed thousands of candidate human disease variants. Establishing which variants cause phenotypes and diseases, however, has remained challenging. Significant progress has been made, includin...

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Bibliographic Details
Main Authors: Dustin Baldridge, Michael F. Wangler, Angela N. Bowman, Shinya Yamamoto, Undiagnosed Diseases Network, Tim Schedl, Stephen C. Pak, John H. Postlethwait, Jimann Shin, Lilianna Solnica-Krezel, Hugo J. Bellen, Monte Westerfield
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Orphanet Journal of Rare Diseases
Subjects:
C. elegans
Drosophila melanogaster
Model organisms
Undiagnosed diseases
Zebrafish
Online Access:https://doi.org/10.1186/s13023-021-01839-9

Internet

https://doi.org/10.1186/s13023-021-01839-9

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