Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Gene Deregulation and Underlying Mechanisms in Spinocerebellar Ataxias With Polyglutamine Expansion

Polyglutamine spinocerebellar ataxias (polyQ SCAs) include SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders caused by the expansion of a CAG repeat sequence located within the coding region of specific genes, which translates into polyglutamin...

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Bibliographic Details
Main Authors: Anna Niewiadomska-Cimicka, Antoine Hache, Yvon Trottier
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neuroscience
Subjects:
polyglutamine
spinocerebellar ataxia
SCA
epigenetic
transcriptional dysregulation
Purkinje cells
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00571/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00571/full

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