Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Cyclin D1-CDK4 activity drives sensitivity to bortezomib in mantle cell lymphoma by blocking autophagy-mediated proteolysis of NOXA

Abstract Background Mantle cell lymphoma (MCL) is an aggressive B-non-Hodgkin lymphoma with generally poor outcome. MCL is characterized by an aberrantly high cyclin D1-driven CDK4 activity. New molecular targeted therapies such as inhibitors of the ubiquitin-proteasome system (UPS) have shown promi...

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Bibliographic Details
Main Authors: Simon Heine, Markus Kleih, Neus Giménez, Kathrin Böpple, German Ott, Dolors Colomer, Walter E. Aulitzky, Heiko van der Kuip, Elisabeth Silkenstedt
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Hematology & Oncology
Subjects:
Mantle cell lymphoma
Bortezomib
NOXA
CDK4
Autophagy
Online Access:http://link.springer.com/article/10.1186/s13045-018-0657-6

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