Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.

Strong signature of natural selection within an FHIT intron implicated in prostate cancer risk.

Previously, a candidate gene linkage approach on brother pairs affected with prostate cancer identified a locus of prostate cancer susceptibility at D3S1234 within the fragile histidine triad gene (FHIT), a tumor suppressor that induces apoptosis. Subsequent association tests on 16 SNPs spanning app...

Full description

Bibliographic Details
Main Authors: Yan Ding, Garrett Larson, Guillermo Rivas, Cathryn Lundberg, Louis Geller, Ching Ouyang, Jeffrey Weitzel, John Archambeau, Jerry Slater, Mary B Daly, Al B Benson, John M Kirkwood, Peter J O'Dwyer, Rebecca Sutphen, James A Stewart, David Johnson, Magnus Nordborg, Theodore G Krontiris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2568805?pdf=render

Internet

http://europepmc.org/articles/PMC2568805?pdf=render

Similar Items