The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

The A2V mutation as a new tool for hindering Aβ aggregation: A neutron and x-ray diffraction study

Abstract We have described a novel C-to-T mutation in the APP gene that corresponds to an alanine to valine substitution at position 673 in APP (A673V), or position 2 of the amyloid-β (Aβ) sequence. This mutation is associated with the early onset of AD-type dementia in homozygous individuals, where...

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Bibliographic Details
Main Authors: Laura Cantu’, Laura Colombo, Tatiana Stoilova, Bruno Demé, Hideyo Inouye, Rachel Booth, Valeria Rondelli, Giuseppe Di Fede, Fabrizio Tagliavini, Elena Del Favero, Daniel A. Kirschner, Mario Salmona
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05582-9

Internet

https://doi.org/10.1038/s41598-017-05582-9

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