Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation
Cancer-associated fibroblasts (CAFs) provide critical metabolites for tumor growth and undergo metabolic reprogramming to support glycolysis. However, the molecular mechanisms responsible for this change remain unclear. Here, we report that TGF-β1- or PDGF-induced CAFs switch from oxidative phosphor...
Main Authors: | Daoxiang Zhang, Yongbin Wang, Zhimin Shi, Jingyi Liu, Pan Sun, Xiaodan Hou, Jian Zhang, Shimin Zhao, Binhua P. Zhou, Jun Mi |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-03-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715001333 |
Similar Items
-
Metabolic reprogramming in mutant IDH1 glioma cells.
by: Jose L Izquierdo-Garcia, et al.
Published: (2015-01-01) -
Molecular Imaging Of Metabolic Reprogramming In Mutant IDH Cells
by: Pavithra eViswanath, et al.
Published: (2016-03-01) -
Metabolic Reprogramming of Cancer Associated Fibroblasts: The Slavery of Stromal Fibroblasts
by: Angelica Avagliano, et al.
Published: (2018-01-01) -
Epigenetic Reprogramming for Targeting <i>IDH</i>-Mutant Malignant Gliomas
by: Jong-Whi Park, et al.
Published: (2019-10-01) -
IDH1 mutation decreases the invasiveness of glioma by downregulating the expression and activity of TAZ
by: Ningning Li, et al.
Published: (2019-01-01)