Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.

Antagonistic cross-regulation between Sox9 and Sox10 controls an anti-tumorigenic program in melanoma.

Melanoma is the most fatal skin cancer, but the etiology of this devastating disease is still poorly understood. Recently, the transcription factor Sox10 has been shown to promote both melanoma initiation and progression. Reducing SOX10 expression levels in human melanoma cells and in a genetic mela...

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Bibliographic Details
Main Authors: Olga Shakhova, Phil Cheng, Pravin J Mishra, Daniel Zingg, Simon M Schaefer, Julien Debbache, Jessica Häusel, Claudia Matter, Theresa Guo, Sean Davis, Paul Meltzer, Daniela Mihic-Probst, Holger Moch, Michael Wegner, Glenn Merlino, Mitchell P Levesque, Reinhard Dummer, Raffaella Santoro, Paolo Cinelli, Lukas Sommer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4309598?pdf=render

Internet

http://europepmc.org/articles/PMC4309598?pdf=render

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