Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli

Oligomannose-Rich Membranes of Dying Intestinal Epithelial Cells Promote Host Colonization by Adherent-Invasive E. coli

A novel mechanism is revealed by which clinical isolates of adherent-invasive Escherichia coli (AIEC) penetrate into the epithelial cell layer, replicate, and establish biofilms in Crohn's disease. AIEC uses the FimH fimbrial adhesin to bind to oligomannose glycans on the surface of host cells....

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Bibliographic Details
Main Authors: Tetiana Dumych, Nao Yamakawa, Adeline Sivignon, Estelle Garenaux, Stefania Robakiewicz, Bernadette Coddeville, Antonino Bongiovanni, Fabrice Bray, Nicolas Barnich, Sabine Szunerits, Christian Slomianny, Martin Herrmann, Sébastien G. Gouin, Alexander D. Lutsyk, Luis E. Munoz, Frank Lafont, Christian Rolando, Rostyslav Bilyy, Julie M. J. Bouckaert
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Microbiology
Subjects:
CEACAM6
adherent-invasive E. coli
apoptotic cell-derived membranous vesicles
oligomannose glycans
Crohn's disease
Online Access:http://journal.frontiersin.org/article/10.3389/fmicb.2018.00742/full

Internet

http://journal.frontiersin.org/article/10.3389/fmicb.2018.00742/full

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