Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling

Bisecting N-Acetylglucosamine on EGFR Inhibits Malignant Phenotype of Breast Cancer via Down-Regulation of EGFR/Erk Signaling

Glycosylation, the most prevalent and diverse post-translational modification of protein, plays crucial biological roles in many physiological and pathological events. Alteration of N-glycan has been detected during breast cancer progression. Among the specific N-glycan structures, bisecting N-Acety...

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Bibliographic Details
Main Authors: Lanming Cheng, Lin Cao, Yurong Wu, Wenjie Xie, Jiaqi Li, Feng Guan, Zengqi Tan
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Oncology
Subjects:
MGAT3
bisecting GlcNAc
glycopeptide
breast cancer
EGFR
EGFR/Erk signaling
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00929/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00929/full

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