Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

Glabridin Prevents Doxorubicin-Induced Cardiotoxicity Through Gut Microbiota Modulation and Colonic Macrophage Polarization in Mice

The chemotherapeutic drug doxorubicin (DOX) provokes a dose-related cardiotoxicity. Thus, there is an urgent need to identify the underlying mechanisms and develop strategies to overcome them. Here we demonstrated that glabridin (GLA), an isoflavone from licorice root, prevents DOX-induced cardiotox...

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Bibliographic Details
Main Authors: Keqing Huang, Yanzhuo Liu, Honglin Tang, Miao Qiu, Chenhong Li, Chenfan Duan, Chenlong Wang, Jing Yang, Xiaoyang Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Pharmacology
Subjects:
glabridin
cardiotoxicity
doxorubicin
gut microbiota
colonic macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00107/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00107/full

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