Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

Multiple non-redundant immunosuppressive pathways co-exist in the tumor microenvironment and their co-targeting can increase clinical responses. Indeed, concurrent blockade of CTLA-4 and PD-1 in patients with advanced melanoma increased clinical responses over monotherapy alone although the frequenc...

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Bibliographic Details
Main Authors: Heidi Harjunpää, Stephen J. Blake, Elizabeth Ahern, Stacey Allen, Jing Liu, Juming Yan, Viviana Lutzky, Kazuyoshi Takeda, Amy Roman Aguilera, Camille Guillerey, Deepak Mittal, Xian Yang Li, William C. Dougall, Mark J. Smyth, Michele W. L. Teng
Format: Article
Language:English
Published: Taylor & Francis Group 2018-07-01
Series:OncoImmunology
Subjects:
pd-1
cd96
tigit
immune homeostasis
tumor immunity
Online Access:http://dx.doi.org/10.1080/2162402X.2018.1445949

Internet

http://dx.doi.org/10.1080/2162402X.2018.1445949

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