Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing <i>RBM20</i> Transcription Through Activation of the MAPK/ELK1 Signaling Pathway

Angiotensin II Influences Pre-mRNA Splicing Regulation by Enhancing <i>RBM20</i> Transcription Through Activation of the MAPK/ELK1 Signaling Pathway

RNA binding motif 20 (RBM20) is a key regulator of pre-mRNA splicing of titin and other genes that are associated with cardiac diseases. Hormones, like insulin, triiodothyronine (T3), and angiotensin II (Ang II), can regulate gene-splicing through RBM20, but the detailed mechanism remains unclear. T...

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Bibliographic Details
Main Authors: Hanfang Cai, Chaoqun Zhu, Zhilong Chen, Rexiati Maimaiti, Mingming Sun, Richard J. McCormick, Xianyong Lan, Hong Chen, Wei Guo
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
rbm20
hormones
insulin
t3
angiotensin ii
pre-mrna splicing
Online Access:https://www.mdpi.com/1422-0067/20/20/5059

Internet

https://www.mdpi.com/1422-0067/20/20/5059

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