iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

iNOS/NO is required for IRF1 activation in response to liver ischemia-reperfusion in mice

Abstract Background Ischemia and reperfusion (I/R) induces cytokines, and up-regulates inducible nitric oxide synthase (iNOS), interferon regulatory factor-1(IRF1) and p53 up-regulated modulator of apoptosis (PUMA), which contribute to cell death and tissue injury. However, the mechanisms that I/R i...

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Bibliographic Details
Main Authors: Qiang Du, Jing Luo, Mu-Qing Yang, Quan Liu, Caroline Heres, Yi-He Yan, Donna Stolz, David A. Geller
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Medicine
Subjects:
Inducible nitric oxide synthase
Interferon regulatory factor-1
Ischemia-reperfusion
Nitric oxide
Histone deacetylase
p53 up-regulated modulator of apoptosis
Online Access:http://link.springer.com/article/10.1186/s10020-020-00182-2

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http://link.springer.com/article/10.1186/s10020-020-00182-2

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