Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.

Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an endocrine disruptor, causes reproductive and developmental toxic effects in pups following maternal exposure in a number of animal models. Our previous studies have demonstrated that TCDD imprints sexual immaturity by suppressing the expression of fetal...

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Bibliographic Details
Main Authors: Takayuki Koga, Takumi Ishida, Tomoki Takeda, Yuji Ishii, Hiroshi Uchi, Kiyomi Tsukimori, Midori Yamamoto, Masaru Himeno, Masutaka Furue, Hideyuki Yamada
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3401201?pdf=render

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http://europepmc.org/articles/PMC3401201?pdf=render

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