GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models

GVHD Pathogenesis, Prevention and Treatment: Lessons From Humanized Mouse Transplant Models

Graft-vs-host disease (GVHD) is the most common cause of non-relapse mortality following allogeneic hematopoietic stem cell transplantation (HSCT) despite advances in conditioning regimens, HLA genotyping and immune suppression. While murine studies have yielded important insights into the cellular...

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Bibliographic Details
Main Authors: Nicholas J. Hess, Matthew E. Brown, Christian M. Capitini
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
graft-versus host disease
xenogeneic transplantation
humanized mouse models
hematopoietic stem cell transplantation
T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.723544/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.723544/full

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