Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?

Can Nimesulide Nanoparticles Be a Therapeutic Strategy for the Inhibition of the KRAS/PTEN Signaling Pathway in Pancreatic Cancer?

Pancreatic cancer is an aggressive, devastating disease due to its invasiveness, rapid progression, and resistance to surgical, pharmacological, chemotherapy, and radiotherapy treatments. The disease develops from PanINs lesions that progress through different stages. KRAS mutations are frequently o...

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Bibliographic Details
Main Authors: Roseane Guimarães Ferreira, Luis Eduardo Mosquera Narvaez, Kaio Murilo Monteiro Espíndola, Amanda Caroline R. S. Rosario, Wenddy Graziela N. Lima, Marta Chagas Monteiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
KRAS
PTEN
nimesulide
solid lipid nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.594917/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.594917/full

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