Rational Design of Alginate Lyase from <i>Microbulbifer</i> sp. Q7 to Improve Thermal Stability

Rational Design of Alginate Lyase from <i>Microbulbifer</i> sp. Q7 to Improve Thermal Stability

Alginate lyase degrades alginate by the &#946;-elimination mechanism to produce oligosaccharides with special bioactivities. The low thermal stability of alginate lyase limits its industrial application. In this study, introducing the disulfide bonds while using the rational design methodology e...

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Bibliographic Details
Main Authors: Min Yang, Su-Xiao Yang, Zhe-Min Liu, Nan-Nan Li, Li Li, Hai-Jin Mou
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Marine Drugs
Subjects:
alginate lyase
thermal stability
rational design
disulfide bond
molecular dynamic simulation
Online Access:https://www.mdpi.com/1660-3397/17/6/378

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https://www.mdpi.com/1660-3397/17/6/378

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