Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.

Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.

Nonalcoholic fatty liver disease (NAFLD) includes a broad range of liver pathologies from simple steatosis to cirrhosis and fibrosis, in which a subtype accompanying hepatocyte degeneration and fibrosis is classified as nonalcoholic steatohepatitis (NASH). NASH accounts for approximately 10-30% of N...

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Main Authors: Takahisa Kawaguchi, Yoshio Sumida, Atsushi Umemura, Keitaro Matsuo, Meiko Takahashi, Toshinari Takamura, Kohichiroh Yasui, Toshiji Saibara, Etsuko Hashimoto, Miwa Kawanaka, Sumio Watanabe, Sumio Kawata, Yasuharu Imai, Miki Kokubo, Toshihide Shima, Hyohun Park, Hideo Tanaka, Kazuo Tajima, Ryo Yamada, Fumihiko Matsuda, Takeshi Okanoue, Japan Study Group of Nonalcoholic Fatty Liver Disease
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3375283?pdf=render

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http://europepmc.org/articles/PMC3375283?pdf=render

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