Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

Simultaneous Determination of Five Alkaloids by HPLC-MS/MS Combined With Micro-SPE in Rat Plasma and Its Application to Pharmacokinetics After Oral Administration of Lotus Leaf Extract

An environment-friendly and efficient method for simultaneous determination of five alkaloids (nunciferine, O-nornuciferin, liriodenine, armepavine, and pronuciferine) in rat plasma was established by HPLC-MS/MS associated with micro-solid phase extraction (micro-SPE). The plasma sample was pretreat...

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Bibliographic Details
Main Authors: Shuhan Zou, Yuanyuan Ge, Xuanhao Chen, Jin Li, Xuejing Yang, Hui Wang, Xiumei Gao, Yan-xu Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Pharmacology
Subjects:
lotus leaf
micro-solid phase extraction
pharmacokinetics
HPLC-MS/MS
PEP-2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01252/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01252/full

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