Hypocretin (orexin) regulation of sleep-to-wake transitions

The hypocretin (Hcrt), also known as orexin, peptides are essential for arousal stability. Here I discuss background information about the interaction of Hcrt with other neuromodulators, including norepinephrine and acetylcholine probed with optogenetics. I conclude that Hcrt neurons integrate metab...

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Bibliographic Details
Main Authors: Luis eDe Lecea, Ramon eHuerta
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00016/full