CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Abstract Background Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cell...

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Bibliographic Details
Main Authors: Shadi Darvish Shafighi, Szymon M. Kiełbasa, Julieta Sepúlveda-Yáñez, Ramin Monajemi, Davy Cats, Hailiang Mei, Roberta Menafra, Susan Kloet, Hendrik Veelken, Cornelis A.M. van Bergen, Ewa Szczurek
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Genome Medicine
Subjects:
Single-cell sequencing
Follicular lymphoma
B cell receptor
Clonal evolution
Somatic mutations
Probabilistic graphical model
Online Access:https://doi.org/10.1186/s13073-021-00842-w

Internet

https://doi.org/10.1186/s13073-021-00842-w

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