A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice:implications for Rett syndrome

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice:implications for Rett syndrome

Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function mutations in the transcriptional modulator methyl-CpG-binding protein 2 (MECP2). One of the most prominent gene targets of MeCP2 is brain-derived neurotrophic factor (Bdnf), a potent modulator of activity-dependent synap...

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Bibliographic Details
Main Authors: Xin eXu, Alan eKozikowski, Lucas ePozzo-Miller
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Rett Syndrome
dense core vesicle
activity-dependent BDNF release
Tubastatin-A
tubulin acetylation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00068/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00068/full

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