Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis. Here, we have determined the functions of ERK/MAPK signaling in developing neocortical excitatory neur...

Full description

Bibliographic Details
Main Authors: Lei Xing, Rylan S Larsen, George Reed Bjorklund, Xiaoyan Li, Yaohong Wu, Benjamin D Philpot, William D Snider, Jason M Newbern
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-02-01
Series:eLife
Subjects:
kinase
excitatory neuron
corticospinal
axon
excitability
Online Access:https://elifesciences.org/articles/11123

Internet

https://elifesciences.org/articles/11123

Similar Items