Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and de...

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Bibliographic Details
Main Authors: Karla Rubio, Indrabahadur Singh, Stephanie Dobersch, Pouya Sarvari, Stefan Günther, Julio Cordero, Aditi Mehta, Lukasz Wujak, Hector Cabrera-Fuentes, Cho-Ming Chao, Peter Braubach, Saverio Bellusci, Werner Seeger, Andreas Günther, Klaus T. Preissner, Malgorzata Wygrecka, Rajkumar Savai, Dulce Papy-Garcia, Gergana Dobreva, Mathias Heikenwalder, Soni Savai-Pullamsetti, Thomas Braun, Guillermo Barreto
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10066-7

Internet

https://doi.org/10.1038/s41467-019-10066-7

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