Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and de...

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Main Authors: Karla Rubio, Indrabahadur Singh, Stephanie Dobersch, Pouya Sarvari, Stefan Günther, Julio Cordero, Aditi Mehta, Lukasz Wujak, Hector Cabrera-Fuentes, Cho-Ming Chao, Peter Braubach, Saverio Bellusci, Werner Seeger, Andreas Günther, Klaus T. Preissner, Malgorzata Wygrecka, Rajkumar Savai, Dulce Papy-Garcia, Gergana Dobreva, Mathias Heikenwalder, Soni Savai-Pullamsetti, Thomas Braun, Guillermo Barreto
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10066-7
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spelling doaj-3d39e90c296449c8bbc1d8a1a253f05c2021-05-11T12:15:28ZengNature Publishing GroupNature Communications2041-17232019-05-0110111610.1038/s41467-019-10066-7Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosisKarla Rubio0Indrabahadur Singh1Stephanie Dobersch2Pouya Sarvari3Stefan Günther4Julio Cordero5Aditi Mehta6Lukasz Wujak7Hector Cabrera-Fuentes8Cho-Ming Chao9Peter Braubach10Saverio Bellusci11Werner Seeger12Andreas Günther13Klaus T. Preissner14Malgorzata Wygrecka15Rajkumar Savai16Dulce Papy-Garcia17Gergana Dobreva18Mathias Heikenwalder19Soni Savai-Pullamsetti20Thomas Braun21Guillermo Barreto22Lung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchLung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchLung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchDepartment of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung ResearchDepartment of Cardiac Development, Max-Planck-Institute for Heart and Lung ResearchLung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchLung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchFaculty of Medicine, Biochemistry Institute, Justus Liebig UniversityFaculty of Medicine, Biochemistry Institute, Justus Liebig UniversityChair for Lung Matrix Remodeling, Excellence Cluster Cardio Pulmonary System, Justus Liebig UniversityGerman Center of Lung Research (Deutsches Zentrum für Lungenforschung, DZL), UGMLCInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal UniversityDepartment of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung ResearchMember of the Excellence Cluster Cardio Pulmonary System (ECCPS), The Universities of Giessen and Marburg Lung Center (UGMLC)Faculty of Medicine, Biochemistry Institute, Justus Liebig UniversityFaculty of Medicine, Biochemistry Institute, Justus Liebig UniversityDepartment of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung ResearchLaboratoire Croissance, Réparation et Régénération Tissulaires (CRRET), CNRS ERL 9215, Université Paris Est Créteil, Université Paris EstAnatomy and Developmental Biology, CBTM, Heidelberg UniversityDivision Chronic Inflammation and Cancer (F180), German Cancer Research Center (DKFZ)Department of Lung Development and Remodeling, Max-Planck-Institute for Heart and Lung ResearchDepartment of Cardiac Development, Max-Planck-Institute for Heart and Lung ResearchLung Cancer Epigenetic, Max-Planck-Institute for Heart and Lung ResearchIdiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.https://doi.org/10.1038/s41467-019-10066-7
collection DOAJ
language English
format Article
sources DOAJ
author Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
spellingShingle Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
Nature Communications
author_facet Karla Rubio
Indrabahadur Singh
Stephanie Dobersch
Pouya Sarvari
Stefan Günther
Julio Cordero
Aditi Mehta
Lukasz Wujak
Hector Cabrera-Fuentes
Cho-Ming Chao
Peter Braubach
Saverio Bellusci
Werner Seeger
Andreas Günther
Klaus T. Preissner
Malgorzata Wygrecka
Rajkumar Savai
Dulce Papy-Garcia
Gergana Dobreva
Mathias Heikenwalder
Soni Savai-Pullamsetti
Thomas Braun
Guillermo Barreto
author_sort Karla Rubio
title Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_short Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_full Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_fullStr Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_full_unstemmed Inactivation of nuclear histone deacetylases by EP300 disrupts the MiCEE complex in idiopathic pulmonary fibrosis
title_sort inactivation of nuclear histone deacetylases by ep300 disrupts the micee complex in idiopathic pulmonary fibrosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-05-01
description Idiopathic pulmonary fibrosis (IPF) is a lethal disease with insufficient treatment strategies. Here the authors show that reduction of the microRNA MIRLET7D and hyperactivation of EP300 contribute to impaired epigenetic silencing by the MiCEE complex in pulmonary fibroblasts of IPF patients, and demonstrate the benefit of inhibiting EP300 for the treatment of IPF.
url https://doi.org/10.1038/s41467-019-10066-7
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