4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

4-methylumbelliferone-mediated polarization of M1 macrophages correlate with decreased hepatocellular carcinoma aggressiveness in mice

Abstract Hepatocellular carcinoma (HCC) arises in the setting of advanced liver fibrosis, a dynamic and complex inflammatory disease. The tumor microenvironment (TME) is a mixture of cellular components including cancer cells, cancer stem cells (CSCs), tumor-associated macrophages (TAM), and dendrit...

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Bibliographic Details
Main Authors: Marcelo M. Rodríguez, Agostina Onorato, María José Cantero, Luciana Domínguez, Juan Bayo, Esteban Fiore, Mariana García, Catalina Atorrasagasti, Ali Canbay, Mariana Malvicini, Guillermo D. Mazzolini
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-85491-0

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https://doi.org/10.1038/s41598-021-85491-0

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