Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level

Interpreting Sequence Variation in PDAC-Predisposing Genes Using a Multi-Tier Annotation Approach Performed at the Gene, Patient, and Cohort Level

We investigated germline variation in pancreatic ductal adenocarcinoma (PDAC) predisposition genes in 535 patients, using a custom-built panel and a new complementary bioinformatic approach. Our panel assessed genes belonging to DNA repair, cell cycle checkpoints, migration, and preneoplastic pancre...

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Bibliographic Details
Main Authors: Michael T. Zimmermann, Angela J. Mathison, Tim Stodola, Douglas B. Evans, Jenica L. Abrudan, Wendy Demos, Michael Tschannen, Mohammed Aldakkak, Jennifer Geurts, Gwen Lomberk, Susan Tsai, Raul Urrutia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
genetic predisposition
medical oncology
precision oncology
genomic data interpretation
survival analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.606820/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.606820/full

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