Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1

Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1

Abstract The 3-hydroxyanthranilic acid (3-HAA), a derivative of kynurenine, was reported to suppress tumor growth. However, the function of 3-HAA largely remains unclear. Here, we report that 3-hydroxyanthranilic acid (3-HAA) is lower in tumor cells, while adding exogenous 3-HAA induces apoptosis in...

Full description

Bibliographic Details
Main Authors: Zhaopeng Shi, Guifang Gan, Xiang Xu, Jieying Zhang, Yuan Yuan, Bo Bi, Xianfu Gao, Pengfei Xu, Wenbin Zeng, Jixi Li, Youqiong Ye, Aiwu Zhou, Naixia Zhang, Wen Liu, Shuhai Lin, Jun Mi
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Journal of Hematology & Oncology
Subjects:
3-Hydroxyanthronic acid (3-HAA)
Kynurenine
YY1
DUSP6
Hepatocellular carcinoma (HCC)
Tryptophan metabolism
Online Access:https://doi.org/10.1186/s13045-021-01165-4

Internet

https://doi.org/10.1186/s13045-021-01165-4

Similar Items