Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Molecular implications of MUC5AC-CD44 axis in colorectal cancer progression and chemoresistance

Abstract Background Differential expression of mucins has been associated with several cancers including colorectal cancer (CRC). In normal physiological conditions, secretory mucin MUC5AC is not expressed in the colonic mucosa, whereas its aberrant expression is observed during development of colon...

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Main Authors: Ramesh Pothuraju, Satyanarayana Rachagani, Shiv Ram Krishn, Sanjib Chaudhary, Rama Krishna Nimmakayala, Jawed A. Siddiqui, Koelina Ganguly, Imayavaramban Lakshmanan, Jesse L. Cox, Kavita Mallya, Sukhwinder Kaur, Surinder K. Batra
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Cancer
Subjects:
Mucins
MUC5AC
CD44
β-Catenin
Colon cancer
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12943-020-01156-y

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http://link.springer.com/article/10.1186/s12943-020-01156-y

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