Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia.

Genomic inverse PCR for exploration of ligated breakpoints (GIPFEL), a new method to detect translocations in leukemia.

Here we present a novel method "Genomic inverse PCR for exploration of ligated breakpoints" (GIPFEL) that allows the sensitive detection of recurrent chromosomal translocations. This technique utilizes limited amounts of DNA as starting material and relies on PCR based quantification of un...

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Bibliographic Details
Main Authors: Elisa Fueller, Daniel Schaefer, Ute Fischer, Pina F I Krell, Martin Stanulla, Arndt Borkhardt, Robert K Slany
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4138100?pdf=render

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http://europepmc.org/articles/PMC4138100?pdf=render

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